Efficacy and safety of firocoxib for the treatment of pain associated with soft tissue surgery in dogs under field conditions in Japan.
Identifieur interne : 000812 ( Main/Exploration ); précédent : 000811; suivant : 000813Efficacy and safety of firocoxib for the treatment of pain associated with soft tissue surgery in dogs under field conditions in Japan.
Auteurs : Yumi Kondo [Japon] ; Kazuaki Takashima ; Satoshi Matsumoto ; Masahiro Shiba ; Tomoko Otsuki ; Gen Kinoshita ; Joseph Rosentel ; Sheila J. Gross ; Candis Fleishman ; Yoshihisa YamaneSource :
- The Journal of veterinary medical science / the Japanese Society of Veterinary Science ; 2012.
English descriptors
- KwdEn :
- 4-Butyrolactone (analogs & derivatives), 4-Butyrolactone (therapeutic use), Animals, Cyclooxygenase Inhibitors (therapeutic use), Dogs (surgery), Double-Blind Method, Least-Squares Analysis, Pain Measurement, Pain, Postoperative (drug therapy), Pain, Postoperative (veterinary), Sulfones (therapeutic use).
- MESH :
- chemical , analogs & derivatives : 4-Butyrolactone.
- chemical , therapeutic use : 4-Butyrolactone, Cyclooxygenase Inhibitors, Sulfones.
- drug therapy : Pain, Postoperative.
- surgery : Dogs.
- veterinary : Pain, Postoperative.
- Animals, Double-Blind Method, Least-Squares Analysis, Pain Measurement.
Abstract
Use of firocoxib in dogs for postoperative pain control has not been published in any of the journals in Japan. A field study was conducted to evaluate the efficacy and safety of firocoxib in dogs in controlling pain associated with soft tissue surgery in Japan. The study followed a negative control, double-blind, multicenter clinical efficacy study using a randomized block design. A total of 131 client-owned dogs presented to the clinical practices for soft tissue surgery were enrolled. Sixty-nine dogs were allocated to the firocoxib-treated group and received 5 mg/kg of firocoxib orally on Day 0 before the surgery and once daily through Day 2, while 62 dogs were allocated to the non-treated group handled in a similar manner only without the firocoxib administration. Pain assessment took place on Day 0 before the surgery through Day 2. The primary efficacy variable was a success/failure variable based on whether the dog needed rescue medication (based on pain assessment after the surgery or Investigator's judgment) and a significant difference between firocoxib-treated group (16.4%) and non-treated group (50.0%) (P=0.0031) was observed. There was no adverse event during the study that was considered to be related to the administration of firocoxib. This study indicated the clinical efficacy and safety profile of firocoxib administered to control pain associated with soft tissue surgery under field condition.
PubMed: 22673062
Affiliations:
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Gross</name></author><author><name sortKey="Fleishman, Candis" sort="Fleishman, Candis" uniqKey="Fleishman C" first="Candis" last="Fleishman">Candis Fleishman</name></author><author><name sortKey="Yamane, Yoshihisa" sort="Yamane, Yoshihisa" uniqKey="Yamane Y" first="Yoshihisa" last="Yamane">Yoshihisa Yamane</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22673062</idno><idno type="pmid">22673062</idno><idno type="wicri:Area/PubMed/Corpus">000263</idno><idno type="wicri:Area/PubMed/Curation">000263</idno><idno type="wicri:Area/PubMed/Checkpoint">000270</idno><idno type="wicri:Area/Ncbi/Merge">000998</idno><idno type="wicri:Area/Ncbi/Curation">000998</idno><idno type="wicri:Area/Ncbi/Checkpoint">000998</idno><idno type="wicri:Area/Main/Merge">000808</idno><idno type="wicri:Area/Main/Curation">000812</idno><idno type="wicri:Area/Main/Exploration">000812</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Efficacy and safety of firocoxib for the treatment of pain associated with soft tissue surgery in dogs under field conditions in Japan.</title><author><name sortKey="Kondo, Yumi" sort="Kondo, Yumi" uniqKey="Kondo Y" first="Yumi" last="Kondo">Yumi Kondo</name><affiliation wicri:level="3"><nlm:affiliation>Merial Japan, Tokyo Opera City Tower, 3-20-2 Nishi Shinjuku, Shinjuku, Tokyo, Japan. yumi.kondo@merial.com</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Merial Japan, Tokyo Opera City Tower, 3-20-2 Nishi Shinjuku, Shinjuku, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Takashima, Kazuaki" sort="Takashima, Kazuaki" uniqKey="Takashima K" first="Kazuaki" last="Takashima">Kazuaki Takashima</name></author><author><name sortKey="Matsumoto, Satoshi" sort="Matsumoto, Satoshi" uniqKey="Matsumoto S" first="Satoshi" last="Matsumoto">Satoshi Matsumoto</name></author><author><name sortKey="Shiba, Masahiro" sort="Shiba, Masahiro" uniqKey="Shiba M" first="Masahiro" last="Shiba">Masahiro Shiba</name></author><author><name sortKey="Otsuki, Tomoko" sort="Otsuki, Tomoko" uniqKey="Otsuki T" first="Tomoko" last="Otsuki">Tomoko Otsuki</name></author><author><name sortKey="Kinoshita, Gen" sort="Kinoshita, Gen" uniqKey="Kinoshita G" first="Gen" last="Kinoshita">Gen Kinoshita</name></author><author><name sortKey="Rosentel, Joseph" sort="Rosentel, Joseph" uniqKey="Rosentel J" first="Joseph" last="Rosentel">Joseph Rosentel</name></author><author><name sortKey="Gross, Sheila J" sort="Gross, Sheila J" uniqKey="Gross S" first="Sheila J" last="Gross">Sheila J. Gross</name></author><author><name sortKey="Fleishman, Candis" sort="Fleishman, Candis" uniqKey="Fleishman C" first="Candis" last="Fleishman">Candis Fleishman</name></author><author><name sortKey="Yamane, Yoshihisa" sort="Yamane, Yoshihisa" uniqKey="Yamane Y" first="Yoshihisa" last="Yamane">Yoshihisa Yamane</name></author></analytic><series><title level="j">The Journal of veterinary medical science / the Japanese Society of Veterinary Science</title><idno type="e-ISSN">1347-7439</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>4-Butyrolactone (analogs & derivatives)</term><term>4-Butyrolactone (therapeutic use)</term><term>Animals</term><term>Cyclooxygenase Inhibitors (therapeutic use)</term><term>Dogs (surgery)</term><term>Double-Blind Method</term><term>Least-Squares Analysis</term><term>Pain Measurement</term><term>Pain, Postoperative (drug therapy)</term><term>Pain, Postoperative (veterinary)</term><term>Sulfones (therapeutic use)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>4-Butyrolactone</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>4-Butyrolactone</term><term>Cyclooxygenase Inhibitors</term><term>Sulfones</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pain, Postoperative</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Dogs</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Pain, Postoperative</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Double-Blind Method</term><term>Least-Squares Analysis</term><term>Pain Measurement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Use of firocoxib in dogs for postoperative pain control has not been published in any of the journals in Japan. A field study was conducted to evaluate the efficacy and safety of firocoxib in dogs in controlling pain associated with soft tissue surgery in Japan. The study followed a negative control, double-blind, multicenter clinical efficacy study using a randomized block design. A total of 131 client-owned dogs presented to the clinical practices for soft tissue surgery were enrolled. Sixty-nine dogs were allocated to the firocoxib-treated group and received 5 mg/kg of firocoxib orally on Day 0 before the surgery and once daily through Day 2, while 62 dogs were allocated to the non-treated group handled in a similar manner only without the firocoxib administration. Pain assessment took place on Day 0 before the surgery through Day 2. The primary efficacy variable was a success/failure variable based on whether the dog needed rescue medication (based on pain assessment after the surgery or Investigator's judgment) and a significant difference between firocoxib-treated group (16.4%) and non-treated group (50.0%) (P=0.0031) was observed. There was no adverse event during the study that was considered to be related to the administration of firocoxib. This study indicated the clinical efficacy and safety profile of firocoxib administered to control pain associated with soft tissue surgery under field condition.</div></front></TEI><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Fleishman, Candis" sort="Fleishman, Candis" uniqKey="Fleishman C" first="Candis" last="Fleishman">Candis Fleishman</name><name sortKey="Gross, Sheila J" sort="Gross, Sheila J" uniqKey="Gross S" first="Sheila J" last="Gross">Sheila J. Gross</name><name sortKey="Kinoshita, Gen" sort="Kinoshita, Gen" uniqKey="Kinoshita G" first="Gen" last="Kinoshita">Gen Kinoshita</name><name sortKey="Matsumoto, Satoshi" sort="Matsumoto, Satoshi" uniqKey="Matsumoto S" first="Satoshi" last="Matsumoto">Satoshi Matsumoto</name><name sortKey="Otsuki, Tomoko" sort="Otsuki, Tomoko" uniqKey="Otsuki T" first="Tomoko" last="Otsuki">Tomoko Otsuki</name><name sortKey="Rosentel, Joseph" sort="Rosentel, Joseph" uniqKey="Rosentel J" first="Joseph" last="Rosentel">Joseph Rosentel</name><name sortKey="Shiba, Masahiro" sort="Shiba, Masahiro" uniqKey="Shiba M" first="Masahiro" last="Shiba">Masahiro Shiba</name><name sortKey="Takashima, Kazuaki" sort="Takashima, Kazuaki" uniqKey="Takashima K" first="Kazuaki" last="Takashima">Kazuaki Takashima</name><name sortKey="Yamane, Yoshihisa" sort="Yamane, Yoshihisa" uniqKey="Yamane Y" first="Yoshihisa" last="Yamane">Yoshihisa Yamane</name></noCountry><country name="Japon"><noRegion><name sortKey="Kondo, Yumi" sort="Kondo, Yumi" uniqKey="Kondo Y" first="Yumi" last="Kondo">Yumi Kondo</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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